This year marks the 5th annual NASH-TAG, a meeting focused solely on NASH drug and diagnostics development. The NASH-TAG format calls for “deep dives” into key issues and combines innovative presentation formats with debates on pivotal issues. Stephen Harrison walks Louise, Roger, and our guest Ian Rowe through the agenda. The panelists raise provocative questions about the agenda and wander into informative conversations about how knowledge develops and how responses to the COVID-19 vaccine may prove instructive in motivating patients. Lots to think about here…and good motivation to register for virtual NASH-TAG.