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S2-E42.2 – How FGFs Work In The Body And What This Means For NAFLD and NASH

Professor Arun Sanyal and Stephen Harrison provide a 40-minute briefing on fibroblast growth factor (FGFs) agents and why they are so important to the future of NASH and NAFLD therapy. The roles fibroblast growth factors (FGFs) play in fat metabolism, appetite and other issues related to Fatty Liver disease.

After a simple opening from Roger Green, this conversation includes 4 key elements:

1:06 – Arun Sanyal discusses the different ways that fibroblast growth factors work in the body
4:21 – Stephen Harrison share some background on how fat gets into the liver in the first place
6:16 – Arun Sanyal describes the specific differences between FGF 2, 3 and 4 receptors in terms of physiologic impact and the role of adiponectin
9:50 – Stephen Harrison and Arun Sanyal comment briefly on the impact of adiponectin in terms of liver scarring

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