S2-E20 – 14-Variable Machine Learning Model Identifies Probable NASH Patients From Electronic Health Records

Jörn Schattenberg discusses NASHmap, the first Machine Learning model that can identify patients likely to have NASH in clinical settings. Louise, Roger and guest Dr. Kris Kowdley join Jörn to consider the model's benefits from academic, patient treatment and statistical perspectives.

Prof. Schattenberg and colleagues built the NASHmap model from a NIDDK database and validated it using the Optum de-identified EHR dataset. The model includes 14 variables, some obvious, others less so, that produce an AUC of 0.82 in the NIDDK database and 0.79 in the Optum database. The episode focuses on how the model was built and what it implies for clinical trial recruitment, patient care and the view it provides of NASH risk factors. This has powerful implications for future clinical trial recruitment and large-scale patient screening.

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