S2-E17.2 — Modeling the relative impact of treating NASH vs. CVD in patients with different fibrosis levels

Ian Rowe presents more findings from his work in Leeds, revealing paradoxes and complexity in the patient screening process. Listen to this conversations to consider the goals for a therapy that, in Ian's words, "treats the patient and not the NASH."
()


Ian Rowe and colleagues have created a model to assess the tradeoff of liver risk reduction vs. CVD risk reduction at different levels of fibrosis and age. The model suggests that for F2 and F3 patients, the cardiovascular profile of a medication may have greater effect on overall morbidity and mortality than the liver profile, even if the drug produces significant liver improvements. The model and its outputs are enlightening, the questions it raises are clinically important. Stephen Harrison shares some recently available data on efruxifermin that suggests a positive effect for compensated cirrhotics, and questions what a drug must do to make sense for earlier stage patients.

How useful was this post?

Click on a star to rate it!

Average rating / 5. Vote count:

No votes so far! Be the first to rate this post.

Request A Transcript of This Episode
Request Transcript
First
Last

Join The Discussion…

Ask Our Panelists A Question…

Podcast Quesitonaire
Is your question directed towards one of our panelists?

If your question is answered in our next Podcast, would you like be tagged?

Join The Discussion!

Subscribe to our free emails. Receive access to our Discussion Group. Ask your questions directly to our "Surfers"